| Diagnosis of gestational diabetes mellitus: is it time for a new critical value? | |
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MedLine Citation:
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PMID: 17694961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To identify the value for the 1-hour glucose tolerance test (GTT) that would maintain 100%, 90% and 75% sensitivity for identifying abnormal 3-hour GTT results in prenatal patients from an East Coast, urban, university hospital setting. STUDY DESIGN: Two hundred forty-two women who underwent the 3-hour GTT during pregnancy between January 1, 2004, and February 1, 2005, at a university hospital laboratory and private laboratories were included. The preceding 1-hour GTT results were obtained from these women, and a receiver operating characteristic (ROC) curve was constructed to identify a 1-hour GTT cutoff value that would maintain 100%, 90% and 75% sensitivity. A subgroup analysis was performed of patients of Asian ethnicity. This study was approved by the institutional review board. RESULTS: To maintain 100% sensitivity of the 1-hour GTT in predicting an abnormal 3-hour GTT, the 1-hour GTT cutoff value could be raised to 144 mg/dL in our population. For 90% and 75% sensitivities, the values were 150 and 156 mg/dL, respectively. There was no clinically significant difference in ROC curve evaluation between Asian and non-Asian groups. CONCLUSION: Raising the current level of 135 mg/dL for a 1-hour GTT to potentially decrease the need for the 3-hour GTT should be considered if larger patient series yield findings similar to those in our population. |
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Authors:
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Erika B Johnston-MacAnanny; Amen Ness; Louis Weinstein |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 52 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-08-14 Completed Date: 2007-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 463-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Thomas Jefferson University Hospital, 834 Chestnut Street, Apartment 617, Philadelphia, PA 19107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes, Gestational
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diagnosis* Female Glucose Tolerance Test / methods* Humans Pregnancy Reference Values Retrospective Studies Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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