Document Detail

Diagnosis of fetal infection in the patient with an ultrasonographically detected abnormality but a negative clinical history.
MedLine Citation:
PMID:  8420349     Owner:  NLM     Status:  MEDLINE    
Unsuspected fetal infection (viral or parasitic) is often overlooked as a possible cause of abnormalities revealed on ultrasonographic examination during pregnancy. Infectious agents can produce a wide spectrum of ultrasonographic findings. Our objective was to highlight those findings and review the rationale and method of antenatal investigation. No ultrasonographic findings are pathognomonic for a particular agent. The search for possible fetal infection consists of both direct and indirect techniques. Methods to directly demonstrate fetal infection include maternal-fetal serologic studies, culture, electron microscopy, and polymerase chain reaction. Emerging evidence strongly suggests that prior assumptions concerning the sensitivity of both maternal and fetal-neonatal serologic studies are incorrect. Serologic studies alone are inadequate to exclude fetal infection as a cause of an ultrasonographically detected abnormality. Indirect techniques suggestive of fetal infection include fetal hematologic and biochemical measurements. New approaches and methods for the detection of fetal infection are needed. The evaluation should be initiated antenatally. Needless delay until after delivery increases the likelihood that the diagnosis will be missed. Antenatal diagnosis provides the opportunity for therapy and often leads the practitioner to modify the obstetric and neonatal care plan. A protocol used by the University of Iowa Fetal Diagnosis and Treatment Unit for the diagnosis and management of unsuspected fetal infection is offered as an example of a protocol that has been successful in the past.
C P Weiner; C F Grose; S J Naides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  168     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6-11     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City 52242.
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MeSH Terms
Fetal Diseases / blood,  diagnosis*,  immunology,  ultrasonography
Microscopy, Electron
Parasitic Diseases / blood,  diagnosis*,  immunology
Polymerase Chain Reaction
Prenatal Diagnosis / methods*
Ultrasonography, Prenatal
Virus Diseases / blood,  diagnosis*,  immunology

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