| Diagnosis delay in patients with ankylosing spondylitis: possible reasons and proposals for new diagnostic criteria. | |
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MedLine Citation:
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PMID: 17899306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ankylosing spondylitis (AS) is a chronic, progressive, and disabling disease. Among the rheumatological diseases, the longest diagnosis delay is still found for AS. The aim of this cross-sectional study is to evaluate the diagnosis delay and possible reasons in AS. A secondary aim is to assess the relation between diagnosis delay and some clinical and laboratory features. One hundred eleven AS patients, (103 male, 8 female) were recruited. A face-to-face interview was applied to take medical history, and a questionnaire that contains some clinical aspects of disease was used. Diagnosis delay was described as the gap between first spondiloarthropathic symptom and correct diagnosis of AS. The average of diagnosis delay was 6.05 +/- 5.08 years. The average age of patients at disease onset was 23.18 +/- 9.59, the average disease duration was 10.44 +/- 8.11, and the average age at diagnosis was 27.88 +/- 11.63. The average diagnosis delay was 5. 3 +/- 3.5 in HLA B 27(+) AS patients, whereas it was 9.2 +/- 7.7 in HLA B 27(-) AS patients (p = 0.037). Diagnosis delay in patients with inflammatory back pain (+) (IBP) at disease onset was lower than IBP (-) patients (3.28 +/- 3.32, 8.57 +/- 8.54; respectively) (p = 0.001). The patients having positive family history had lower diagnosis delay than those with negative family history (4.60 +/- 4.44, 10.00 +/- 2.30; respectively) (p = 0.003). The diagnosis delay is a challenge and an important problem for patients with AS and physicians. HLA B27 and family history should be considered while making new criteria. Inflammatory back pain should be emphasized as the main screening criterion for primary care physicians. These clinical and laboratory features had positive effect on the average diagnosis delay in AS patients. Describing new diagnostic criteria, which is more useful to diagnosis of AS, is necessary. |
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Authors:
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Umit Dincer; Engin Cakar; M Zeki Kiralp; Hasan Dursun |
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Publication Detail:
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Type: Journal Article Date: 2007-09-26 |
Journal Detail:
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Title: Clinical rheumatology Volume: 27 ISSN: 0770-3198 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-12 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Belgium |
Other Details:
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Languages: eng Pagination: 457-62 Citation Subset: IM |
Affiliation:
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Department of Physical Medicine and Rehabilitation, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey. drumitdincer@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Back Pain / diagnosis, etiology Cross-Sectional Studies Disease Progression Early Diagnosis* Female HLA-B27 Antigen / blood Humans Male Medical History Taking Middle Aged Spondylitis, Ankylosing / complications, diagnosis*, immunology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/HLA-B27 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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