Document Detail

Diagnosis of defects in oxidative muscle metabolism by non-invasive tissue oximetry.
MedLine Citation:
PMID:  9309658     Owner:  NLM     Status:  MEDLINE    
The dynamics of oxygen delivery and utilization are examined in a variety of mitochondrial disorders during rest, exercise and post exercise. We used a non-invasive optical technique to measure the oxygen consumption in the exercising limb in normal subjects and 5 patients with cytochrome c oxidase deficiency. We also examined 6 patients with MELAS and MERRF syndrome. We measured near-infrared spectra of hemoglobin in the gastrocnemius muscle during treadmill exercise. Normal subjects demonstrated a sustained deoxygenation during exercise, indicating an efficient utilization of delivered oxygen. Patients with cytochrome c oxidase deficiency demonstrated consistent oxygenation during exercise indicating an under utilization of delivered oxygen. Patients with MELAS and MERRF syndrome showed similar under utilization of oxygen during exercise. Non-invasive tissue oximetry during exercise demonstrates specific abnormalities in a variety of mitochondrial disorders, indicating abnormal oxygen utilization, and will be a useful addition to the clinical investigation of such disorders.
W Bank; B Chance
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  174     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-03     Completed Date:  1997-11-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  7-10     Citation Subset:  IM    
Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA.
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MeSH Terms
Cytochrome-c Oxidase Deficiency*
MELAS Syndrome / diagnosis*,  metabolism,  pathology
MERRF Syndrome / diagnosis*,  metabolism,  pathology
Muscle, Skeletal / metabolism*
Oxygen / analysis*
Reg. No./Substance:

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