Document Detail

Diagnosis of deep-vein thrombosis using an objective Doppler method.
MedLine Citation:
PMID:  2190519     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To determine the diagnostic criteria (phase I) and to assess the accuracy (phase II) of an objective Doppler-Valsalva pressure method as compared with contrast venography for the diagnosis of acute deep-leg-vein thrombosis in symptomatic outpatients. DESIGN: A two-phase prospective study in consecutive patients. Doppler ultrasound strip-chart recordings and venograms were independently analyzed by experienced observers. SETTING: Referral-based medical clinics at university medical centers. PATIENTS: One hundred and ten (phase I) and one hundred and fifty-five (phase II) patients who had clinically suspected venous thrombosis and were referred by their general practitioners were included. METHODS AND MEASUREMENTS: A normal Doppler test result was defined as a cyclic spontaneous signal (S-signal), a continuous S-signal with a Valsalva pressure of less than 6.5 mm Hg, or an absent S-signal with flow after cessation of the Valsalva maneuver. A continuous S-signal with a Valsalva pressure of 6.5 mm Hg or more or an absent S-signal without flow after cessation of the Valsalva maneuver were defined as abnormal test results. The accuracy indices for proximal vein thrombosis in phase II (155 patients; prevalence, 31%) were sensitivity, 91% (95% CI, 79% to 98%), and specificity, 99% (CI, 97% to 100%). All 3 patients with isolated calf-vein thrombosis had normal Doppler test results. CONCLUSIONS: The objective Doppler method is an accurate, reproducible, and simple method for detection of venous thrombosis in symptomatic outpatients.
A W Lensing; M M Levi; H R Büller; P Prandoni; M Vigo; G Agnelli; L Lupatelli; M V Huisman; J W ten Cate
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of internal medicine     Volume:  113     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-07-12     Completed Date:  1990-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  AIM; IM    
Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Abdomen / physiology
Aged, 80 and over
Clinical Protocols
Leg / blood supply
Middle Aged
Observer Variation
Predictive Value of Tests
Prospective Studies
Regional Blood Flow
Reproducibility of Results
Thrombophlebitis / diagnosis*
Transducers, Pressure
Ultrasonography / methods*
Valsalva Maneuver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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