Document Detail

Diagnosis of coronary artery disease by estimation of coronary sinus lactate.
MedLine Citation:
PMID:  708539     Owner:  NLM     Status:  MEDLINE    
In an attempt to assess the value of coronary sinus lactate estimation before and during atrial pacing for the diagnosis of obstructive coronary artery disease, 70 patients with angina were investigated in this way and by selective coronary arteriography. Thirty-five had radiologically normal coronary arteries and 35 had coronary artery disease. When the change in coronary arteriovenous lactate difference was less than 0.09 mmol/l (0.8 mg/100 ml) between the control and the peak atrial pacing sample, the coronary arteries were normal except in one patient who had distal disease of a single vessel. When the change was greater than 0.22 mmol/l (2.0 mg/100 ml) coronary artery disease was always found, and when the change was greater than 0.39 mmol/l (3.5 mg/100 ml) there was always disease of two or three vessels. Unfortunately, the presence or absence of coronary artery disease could not be predicted when the change fell between 0.09 and 0.22 mmol/l (0.8 and 2.0 mg/100 ml). Estimation of coronary sinus lactate before and during atrial pacing can thus frequently distinguish patients with normal coronary arteries from those with coronary artery disease.
G Jackson; L Atkinson; M Clark; B Crook; P Armstrong; S Oram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  40     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  979-83     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / blood,  diagnosis*
Cardiac Pacing, Artificial
Coronary Disease / diagnosis*
Coronary Vessels
Exercise Test
Lactates / blood*
Lipids / blood
Middle Aged
Reg. No./Substance:
0/Lactates; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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