| Diagnosis of congenital syphilis by combining Treponema pallidum-specific IgM detection with immunofluorescent antigen detection for T. pallidum. | |
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MedLine Citation:
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PMID: 8515119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most infants at risk for congenital syphilis can be identified easily by a positive maternal serologic test for syphilis. However, a diagnosis of congenital syphilis can be difficult to make in an individual infant. Seven infants with delayed-onset congenital syphilis and 101 newborns at risk for congenital syphilis were evaluated for characteristic physical findings and laboratory-detectable abnormalities of congenital syphilis. By using a combination of Western blot for T. pallidum-specific IgM detection and immunofluorescent antigen detection for the identification of T. pallidum, a diagnosis of congenital syphilis was made in all 7 infants with delayed-onset congenital syphilis and 24 of the 101 newborns at risk for congenital syphilis. However, T. pallidum-specific IgM was negative in 6 of the 24 newborns with congenital syphilis. T. pallidum-specific IgM detection alone is inadequate for the diagnosis of congenital syphilis. |
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Authors:
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K Bromberg; S Rawstron; G Tannis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 168 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-07-20 Completed Date: 1993-07-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 238-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Children's Medical Center of Brooklyn, New York 11203. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Bacterial
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analysis Antigens, Bacterial / analysis Blotting, Western Fluorescent Antibody Technique Humans Immunoglobulin M / analysis Infant, Newborn Syphilis Serodiagnosis / methods Syphilis, Congenital / diagnosis* Treponema pallidum / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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