| Diagnosis of chronic pancreatitis by measurement of lactoferrin in duodenal juice. | |
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MedLine Citation:
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PMID: 7250745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lactoferrin is a non-enzymatic secretory protein of human pancreas and is specifically increased in pancreatic juice of patients with chronic pancreatitis. Duodenal contents being easier to obtain than pure pancreatic juice, the possibility of using lactoferrin measurement in duodenal juice as a diagnosis test for chronic pancreatitis was explored. Forty-eight patients were studied. Duodenal juice was obtained devoid of salivary contamination by a special double lumen tube. Under these conditions lactoferrin secretion (concentration and output) is increased in patients with chronic pancreatitis. When expressed as the ratio of lactoferrin to lipase units, there was no overlap between chronic pancreatitis and other pancreatic disease or controls. The simplicity and the reproducibility of the technique on a material as readily available as duodenal juice confirms the diagnostic value of lactoferrin measurement in the assessment of patients with suspected pancreatic disease. |
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Authors:
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L Multigner; C Figarella; H Sarles |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 22 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1981 May |
Date Detail:
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Created Date: 1981-09-22 Completed Date: 1981-09-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 350-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chronic Disease Chymotrypsin / analysis Duodenum / analysis* Female Humans Intestinal Secretions / analysis* Lactoferrin / analysis*, secretion Lactoglobulins / analysis* Lipase / analysis Male Middle Aged Pancreatitis / diagnosis* Phospholipases / analysis |
| Chemical | |
Reg. No./Substance:
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0/Lactoferrin; 0/Lactoglobulins; EC 3.1.-/Phospholipases; EC 3.1.1.3/Lipase; EC 3.4.21.1/Chymotrypsin |
| Comments/Corrections | |
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