Document Detail

Diagnosis of acute renal failure in very preterm infants.
MedLine Citation:
PMID:  15249758     Owner:  NLM     Status:  MEDLINE    
This study was designed to improve the definition of acute renal failure (ARF) in very preterm infants. Twenty-eight newborn infants with gestational age < or =32 weeks were prospectively studied in the first 5 days of life and made up a control group as they did not present risk factors for vasomotor renal insufficiency. Renal insufficiency was defined as an increase in daily serum creatinine concentration above the 99th interval limit obtained in this control group, i.e., 43 micromol/l on day 1 and/or 21 micromol/l on day 2 and/or 14 micromol/l/day on day 3 and/or 22 micromol/l/day on day 4. According to this definition, 20 very preterm infants with ARF were identified. As compared with the control group, the ARF group showed more prolonged oliguric episodes, lower diuresis, insufficient weight loss (in spite of a reduction in water intake) and also more episodes with natremia <130 mEq/l (35 vs. 0%; p <0.05) and/or kalemia >6 mEq/l (40 vs. 11%; p <0.05). Therefore, assessment of daily changes in serum creatinine concentration in very preterm infants allows the diagnosis of clinically significant reduction in glomerular filtration rate.
G Choker; J B Gouyon
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Publication Detail:
Type:  Journal Article     Date:  2004-07-07
Journal Detail:
Title:  Biology of the neonate     Volume:  86     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-01     Completed Date:  2005-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  212-6     Citation Subset:  IM    
Service de Pédiatrie 2, Dijon, France.
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MeSH Terms
Bicarbonates / blood
Creatinine / blood
Gestational Age
Glomerular Filtration Rate
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / diagnosis*
Kidney Failure, Acute / diagnosis*
Potassium / blood
Prospective Studies
Reference Values
Sodium / blood
Weight Loss
Reg. No./Substance:
0/Bicarbonates; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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