| Diagnosis and Management of Pernicious Anemia. | |
| | |
MedLine Citation:
|
PMID: 21947876 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Pernicious anemia is a macrocytic anemia due to cobalamin deficiency, which is the result of intrinsic factor deficiency. Pernicious anemia is associated with atrophic body gastritis, whose diagnostic criteria are based on the histologic evidence of gastric body atrophy associated with hypochlorhydria. Serological markers suggesting the presence of oxyntic mucosa damage are increased levels of fasting gastrin and decreased levels of Pepsinogen I. Without the now obsolete Schilling's test, intrinsic factor deficiency may not be proven, and gastric intrinsic factor output after pentagastric stimulation has been proposed. Intrinsic factor autoantibodies are useful surrogate markers of pernicious anemia. The management of patients with pernicious anemia should focus on the life-long replacement treatment with cobalamin and the monitoring to early diagnose an eventual onset of iron deficiency. Moreover, these patients should be advised about possible gastrointestinal long-term consequences, such as gastric cancer and carcinoids. |
| | |
Authors:
|
Bruno Annibale; Edith Lahner; Gianfranco Delle Fave |
Related Documents
:
|
2792656 - Manometric responses to balloon distention in patients with nonobstructive dysphagia. 10913986 - Transnasal gastroscopy. 7234836 - Esophageal disease in patients with angina-like chest pain. 22456776 - Iron deficiency can cause cognitive impairment in geriatric patients. 8555076 - Experience with liposomal amphotericin-b in 60 patients undergoing high-dose therapy an... 20147886 - Age and comorbidity may explain the paradoxical association of an early dialysis start ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-21 |
Journal Detail:
|
Title: Current gastroenterology reports Volume: - ISSN: 1534-312X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Digestive and Liver Disease, University Sapienza, Medical School, Ospedale Sant'Andrea, Via di Grottarossa 1035, 00189, Rome, Italy, bruno.annibale@uniroma1.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High-resolution genomic profiling of an adult Wilms' tumor: evidence for a pathogenesis distinct fro...
Next Document: Monitoring of cotton dust and health risk assessment in small-scale weaving industry.