| Diagnosis of blastomycosis in surgical pathology and cytopathology: correlation with microbiologic culture. | |
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MedLine Citation:
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PMID: 20090507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blastomycosis, a worldwide disease caused by the inhalation of Blastomyces dermatitidis spores, can be diagnosed by microbiologic culture or morphologic identification in tissue or cytologic material. A retrospective review of cases diagnosed as blastomycosis in surgical pathology and cytopathology was undertaken at a University Medical Center to assess the diagnostic value of morphologic methods and their correlation with microbiologic cultures. Surgical pathology/cytology records were reviewed for the period between January 1998 and April 2007 and 53 cases diagnosed as blastomycosis were retrieved: 38 males, 15 females; age 14 to 77 years, median 48. Twenty-nine cases (54.7%) involved lung, 14 (26.4%) soft tissue/bone, 5 (9.4%) skin, 3 (5.6%) other sites, and 2 (3.7%) involved both lung and skin. Forty-six of the 53 patients (87%) had concomitant cultures: 31 (67.4%) were positive for blastomycosis, 11 (23.9%) negative and 4 (8.7%) showed other fungal organisms. A review of microbiology laboratory results for the same period identified a total of 39 patients who were diagnosed with blastomycosis based on isolation of B. dermatitidis. These included 31 cases (79.5%) that were also diagnosed on histology/cytology specimens, 4 (10.25%) that were not submitted to surgical pathology and 4 (10.25%) cases in which pathologic examination failed to identify Blastomyces. This study shows that blastomycosis encountered in surgical/cytopathology can be reliably diagnosed by morphologic examination allowing for prompt treatment. However, microbiologic cultures still play a major role in clinical management of patients suspected of infection because 10.25% were false negative on morphology in our study. |
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Authors:
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Ajay Jitendra Patel; Paolo Gattuso; Vijaya B Reddy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of surgical pathology Volume: 34 ISSN: 1532-0979 ISO Abbreviation: Am. J. Surg. Pathol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 256-61 Citation Subset: IM |
Affiliation:
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Department of Pathology, Rush University Medical Center, 1750 W. Harrison St., Chicago IL 60612, USA. ajay_patel@rush.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blastomyces / cytology, isolation & purification*, physiology Blastomycosis / diagnosis*, therapy Female Humans Male Microbiological Techniques Middle Aged Predictive Value of Tests Reproducibility of Results Retrospective Studies Young Adult |
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