| Diagnosis of 22 new cases of Bartonella endocarditis. | |
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MedLine Citation:
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PMID: 8849149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Bartonella species are emerging pathogens that are seldom reported as a cause of blood culture-negative endocarditis. OBJECTIVE: To report the occurrence of, risk factors for, and clinical features of Bartonella endocarditis and to evaluate the diagnostic tools available for this condition. DESIGN: Case series and comparison with past series. SETTING: Multicenter international study in Halifax, Nova Scotia, Canada; Lyon, France; and Marseille, France. PATIENTS: 22 patients from France, England, Canada, and South Africa were investigated for blood culture-negative endocarditis. MEASUREMENTS: Titer of antibodies to Bartonella species by microimmunofluorescence assay, blood or vegetation culture, and amplification of Bartonella DNA from valvular tissue by polymerase chain reaction. Cross-adsorption was done for patients with antibodies to Chlamydia species. RESULTS: 22 patients had definite endocarditis. Five were infected with B. quintana, 4 with B. henselae, and 13 with an undetermined Bartonella species. These cases were compared with the 11 previously reported cases. Of the patients with the newly reported cases, 19 had valvular surgery and 6 died. Nine were homeless, 11 were alcoholic, 4 owned cats, and 13 had preexisting valvular heart disease. Bartonella species caused 3% of the cases of endocarditis seen in the three study centers. The patients with these cases could have previously received a diagnosis of chlamydial endocarditis because of apparently high levels of cross-reacting antibodies to Chlamydia species. CONCLUSIONS: Bartonella species are an important cause of blood culture-negative endocarditis and can be identified by culture, serologic studies, or molecular biology techniques. Alcoholism and homelessness without previous valvular heart disease are risk factors for B. quintana infection but not for infection with other Bartonella species. |
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Authors:
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D Raoult; P E Fournier; M Drancourt; T J Marrie; J Etienne; J Cosserat; P Cacoub; Y Poinsignon; P Leclercq; A M Sefton |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of internal medicine Volume: 125 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 646-52 Citation Subset: AIM; IM |
Affiliation:
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Unité des Rickettsies, CNRS EPJ0054, Faculté de Médecine, Marseille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alcoholism / complications Animals Animals, Domestic Antibodies, Bacterial / analysis, immunology Bartonella / immunology, isolation & purification Bartonella Infections / complications, diagnosis* Base Sequence Cats Chlamydia / immunology Cross Reactions DNA Primers DNA, Bacterial / analysis Endocarditis, Bacterial / complications, diagnosis*, microbiology Female Homeless Persons Humans Male Middle Aged Molecular Sequence Data Prospective Studies Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/DNA Primers; 0/DNA, Bacterial |
| Comments/Corrections | |
Erratum In:
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Ann Intern Med 1997 Aug 1;127(3):249 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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