Document Detail


Diagnosing malaria in pregnancy: an update.
MedLine Citation:
PMID:  23199403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy malaria (PM) due to Plasmodium falciparum is a major cause of morbidity and mortality for women and their offspring, but is difficult to recognize and diagnose. During PM, parasites typically sequester in the placenta, whereas peripheral blood smears often appear negative. In addition, many infected women remain asymptomatic, especially in areas of high transmission where systemic immunity is high, although sequelae including maternal anemia and intrauterine growth retardation develop insidiously and increase mortality. New rapid diagnostic tests (RDTs) have shown promise for malaria diagnosis in nonpregnant individuals, including a product recently approved by the US FDA for use in the USA. However, the sensitivity and specificity of RDTs for diagnosis of PM may be suboptimal. Here, we review the methods that are used to detect or diagnose PM, including blood smear microscopy, RDTs, PCR-based methods, and finally placental histology, which is often cited as the gold standard for use in research studies and clinical trials.
Authors:
Michal Fried; Atis Muehlenbachs; Patrick E Duffy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of anti-infective therapy     Volume:  10     ISSN:  1744-8336     ISO Abbreviation:  Expert Rev Anti Infect Ther     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-20     Revised Date:  2013-08-11    
Medline Journal Info:
Nlm Unique ID:  101181284     Medline TA:  Expert Rev Anti Infect Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1177-87     Citation Subset:  IM    
Affiliation:
Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20892, USA. michal.fried@nih.gov
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MeSH Terms
Descriptor/Qualifier:
Disease Susceptibility / epidemiology
Female
Hemeproteins / chemistry
Humans
Infant, Low Birth Weight
Infant, Newborn
Malaria, Falciparum / diagnosis*,  epidemiology
Placenta / parasitology
Pregnancy
Pregnancy Complications, Hematologic / diagnosis,  parasitology
Pregnancy Complications, Parasitic / diagnosis*,  epidemiology
Pregnancy Outcome
Grant Support
ID/Acronym/Agency:
5U19AI065664/AI/NIAID NIH HHS; AI52059/AI/NIAID NIH HHS; ZIA AI001153-01/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Hemeproteins; 39404-00-7/hemozoin
Comments/Corrections

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