Document Detail


Diagnosing heart failure with preserved ejection fraction.
MedLine Citation:
PMID:  23930995     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction: Heart failure with preserved ejection fraction (HFPEF) is a common syndrome, accounting for about 50% of all patients with heart failure (HF). Morbidity and mortality are similar to patients with HF with reduced ejection fraction (HFREF), yet no effective treatment has been identified in randomized clinical trials. Areas covered: This article provides an overview of the available literature regarding diagnosing established HFPEF and potential new therapeutic targets for the early diagnosis of HFPEF. Vascular dysfunction, ventricular-arterial coupling, oxidative stress, extracellular matrix regulation, chronotropic incompetence, pulmonary hypertension, exercise testing and biomarkers were taken into consideration next to conventional measurements of diastolic dysfunction. Expert opinion: Measuring diastolic dysfunction in HFPEF is considered important in many patients. Nevertheless, today we know that other causes besides diastolic dysfunction are also involved in the pathophysiology of many HFPEF patients and need to be investigated in order to make a correct diagnosis. Therefore, further research is required to allow better and more specific diagnostic and treatment options to reduce the morbidity and mortality for this ever-expanding HF population.
Authors:
Peter Moritz Becher; Diana Lindner; Nina Fluschnik; Stefan Blankenberg; Dirk Westermann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-9
Journal Detail:
Title:  Expert opinion on medical diagnostics     Volume:  -     ISSN:  1753-0067     ISO Abbreviation:  Expert Opin Med Diagn     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392201     Medline TA:  Expert Opin Med Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University Heart Center Hamburg Eppendorf, Department of General and Interventional Cardiology , Martinistraße 52, 20246 Hamburg , Germany dirk.westermann@web.de.
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