Document Detail

Diagnosing early Lyme disease.
MedLine Citation:
PMID:  3970049     Owner:  NLM     Status:  MEDLINE    
The diagnostic value of clinical, culture, and serologic findings was studied prospectively in 41 patients with early Lyme disease. Fifteen patients had erythema chronicum migrans alone, and 26 had clinical evidence of disseminated infection, most commonly affecting the brain or meninges, other skin sites, lymph nodes, or joints. Of 40 blood cultures, only one, from a patient with disseminated infection, yielded spirochetes. One of 10 patients tested with localized infection had an elevated IgM response to the Lyme spirochete (200 units or greater) during acute disease. Two to three weeks after beginning antibiotic therapy, four of the 10 patients had elevated specific IgM or IgG responses (200 units or greater). Of the 22 patients tested with disseminated disease, 10 initially had elevated levels of specific IgM or IgG, and 12 had such responses by convalescence. Because of the low yield of cultures and the delay in the specific antibody response, recognition of the clinical picture remains very important in diagnosing early Lyme disease.
M Shrestha; R L Grodzicki; A C Steere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  78     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-03-05     Completed Date:  1985-03-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Bacterial / biosynthesis
Bites and Stings / complications
Child, Preschool
Erythema / etiology*
Immunoglobulin G / biosynthesis
Immunoglobulin M / biosynthesis
Lyme Disease / diagnosis*,  etiology,  immunology
Middle Aged
Prospective Studies
Spirochaetales / immunology,  isolation & purification
Time Factors
Grant Support
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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