Document Detail


Diacyl glycerol arginine-based surfactants: biological and physicochemical properties of catanionic formulations.
MedLine Citation:
PMID:  20676901     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In this paper, we report on a catanionic vesicles-based strategy to reduce the cytotoxicity of the diacyl glycerol arginine-based synthetic surfactants 1,2-dimyristoyl-rac-glycero-3-O-(N(α)-acetyl-L-arginine) hydrochloride (1414RAc) and 1,2-dilauroyl-rac-glycero-3-O-(N(α)-acetyl-L-arginine) hydrochloride (1212RAc). The behavior of these surfactants was studied either as pure components or after their formulation as pseudo-tetra-chain catanionic mixtures with phosphatidylglycerol (PG) and as cationic mixtures with 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) used as control. The antimicrobial activity of the negatively charged formulations against Acinetobacter baumannii was maintained with respect to the surfactant alone, while a significant improvement of the antimicrobial activity against Staphylococcus aureus was observed, together with a strong decrease of hemolytic activity. The influence of the net charge of the catanionic vesicles on membrane selectivity was studied using model membranes. The dynamics of surface tension changes induced by the addition of 1414RAc/PG aqueous dispersions into phospholipid monolayers composed of zwitterionic DPPC as model system for mammalian membranes and of negatively charged PG mimicking cytoplasmic membrane of gram-positive bacteria was followed by tensiometry. Our results constitute a proof of principle that tuning formulation can reduce the cytotoxicity of many surfactants, opening their possible biological applications.
Authors:
Neus Lozano; Lourdes Pérez; Ramon Pons; Aurora Pinazo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-31
Journal Detail:
Title:  Amino acids     Volume:  40     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  721-9     Citation Subset:  IM    
Affiliation:
Departament de Tecnologia Química i de Tensioactius, Institut de Química Avançada de Catalunya, CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain.
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