Document Detail

Diacridines: bifunctional intercalators. III. Definition of the general site of action.
MedLine Citation:
PMID:  1247547     Owner:  NLM     Status:  MEDLINE    
Electron microscopy of HeLa cells exposed to spermine diacridine shows nucleolar distortions which disappear after several days despite the persistence of the metabolic changes promoted by spermine diacridine. This compound inhibits ribosomal RNA synthesis and appears to act independently of any particular phase of the cell cycle. The DNA content of the HeLa cells remains unchanged and the cell distribution is not significantly disturbed from its normal distribution in the various phases of the cell cycle. Spermine diacridine and other diacridines inhibit primarily chain initiation but also chain elongation by DNA-directed RNA polymerase of Azotobacter vinelandii.
E S Canellakis; V Bono; R A Bellantone; J S Krakow; R M Fico; R A Schulz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  418     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-27     Completed Date:  1976-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  300-14     Citation Subset:  IM    
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MeSH Terms
Acridines / pharmacology*
Cell Division / drug effects
Cell Nucleolus / drug effects,  metabolism*,  ultrastructure
DNA, Neoplasm / metabolism
Hela Cells / drug effects,  metabolism*,  ultrastructure
Microscopy, Electron
Spermine / pharmacology*
Structure-Activity Relationship
Reg. No./Substance:
0/Acridines; 0/DNA, Neoplasm; 71-44-3/Spermine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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