Document Detail

Diacridines: bifunctional intercalators. II. The biological effects of putrescine, sperimidine and spermine diacridines on HeLa cells and on the L-1210 and P-388 leukemia cells.
MedLine Citation:
PMID:  1247546     Owner:  NLM     Status:  MEDLINE    
The effect of putrescine, spermidine and spermine diacridines on the growth of HeLa cells and of P-388 and L-1210 leukemia cells has been evaluated and compared to that of the parent compound, 9-aminoacridine. The diacridines are more effective growth inhibitors than 9-aminoacridine. The primary site of action appears to be the inhibition of RNA synthesis.
E S Canellakis; R A Bellantone
Related Documents :
11991756 - Rep/cap gene amplification and high-yield production of aav in an a549 cell line expres...
16960656 - Downregulation of hnrnp c1/c2 by sirna sensitizes hela cells to various stresses.
2985616 - Substrate-dependent differences in growth and biological properties of fibroblasts and ...
16599186 - Lymphocytic choriomeningitis virus mx strain does not induce the expression of tumor-as...
15871486 - A three-dimensional collagen matrix as a suitable culture system for the comparison of ...
19841656 - Harpins and ion channels modulations: many ways to die.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  418     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-04-27     Completed Date:  1976-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  290-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acridines / pharmacology*
Cell Division / drug effects
Hela Cells / drug effects,  metabolism*
Leukemia L1210 / metabolism*
Leukemia, Experimental / metabolism*
Protein Biosynthesis / drug effects
Putrescine / pharmacology*
Spermidine / pharmacology*
Spermine / pharmacology*
Structure-Activity Relationship
Reg. No./Substance:
0/Acridines; 110-60-1/Putrescine; 124-20-9/Spermidine; 71-44-3/Spermine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diacridines: bifunctional intercalators. I. Chemistry, physical chemistry and growth inhibitory prop...
Next Document:  Diacridines: bifunctional intercalators. III. Definition of the general site of action.