Document Detail


Diabetic type of cardiomyopathy in food-restricted rats.
MedLine Citation:
PMID:  1451026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have demonstrated that food restriction that is associated with weight loss can produce a type of cardiac dysfunction similar to that produced by diabetes. As in diabetic atria, the food-restricted atria had a 2-fold increase in contraction force, rate of force development, and rate of force decline compared with controls. Both food-restricted and diabetic atria could tolerate anoxia better than controls. The contractile function of the whole perfused heart from the food-restricted rat was reduced, as in the case of the diabetic heart. As the left ventricular volume was increased, the left ventricular developed pressure and the rate of rise and fall in pressure were significantly reduced in both food-restricted and diabetic hearts, compared with those of age- and weight-matched controls. The positive inotropic responses of atria and whole perfused heart to increasing concentrations of extracellular calcium were similarly altered in food-restricted and diabetic hearts. The possible molecular mechanisms of these findings and some of the differences observed between food-restricted and diabetic hearts are discussed.
Authors:
F Savabi; A Kirsch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  70     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1040-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Nutrition, University of Southern California, School of Medicine, Los Angeles 90033.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Animals
Blood Glucose / metabolism
Calcium / pharmacology
Cardiomyopathies / pathology*
Diabetes Mellitus, Experimental / pathology,  urine
Diabetic Angiopathies / pathology*,  urine
Diet, Reducing / adverse effects*
Insulin / pharmacology
Male
Myocardial Contraction / physiology
Phosphocreatine / metabolism
Rats
Rats, Sprague-Dawley
Ventricular Function, Left / physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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