| Diabetic retinopathy in the SEARCH for Diabetes in Youth Cohort: a pilot study. | |
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MedLine Citation:
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PMID: 22269205 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: The aim of this pilot study was to generate an initial estimate of the prevalence and correlates of diabetic retinopathy in a racially and ethnically diverse sample of youth with Type 1 and Type 2 diabetes mellitus. Methods: A pilot study was conducted among 222 individuals with Type 1 diabetes (79% non-Hispanic white, 21% other) and 43 with Type 2 diabetes (28% non-Hispanic white, 72% other), all of > 5 years duration (mean duration 6.8 years) who participated in the SEARCH for Diabetes in Youth study. Diabetic retinopathy was assessed using non-mydriatic retinal photography of both eyes. Results: The prevalence of diabetic retinopathy was 17% for Type 1 diabetes and 42% for Type 2 diabetes (odds ratio 1.50, 95% CI 0.58-3.88; P = 0.40 adjusted for age, duration, gender, race/ethnicity, parental education and HbA(1c) . HbA(1c) was significantly higher among those with any diabetic retinopathy (adjusted mean 79 mmol/mol, 9.4%) vs. no diabetic retinopathy (adjusted mean 70 mmol/mol, 8.6%) (P = 0.015). LDL cholesterol was also significantly higher among those with any diabetic retinopathy (adjusted mean 107.2 mg/dl) compared with those without diabetic retinopathy (adjusted mean 97.9 mg/dl) (P = 0.04). Conclusions: The prevalence of diabetic retinopathy in contemporary young individuals was substantial, particularly among minority youth and those with Type 2 diabetes. Further long-term study of diabetic retinopathy in youth is needed. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. |
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Authors:
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E J Mayer-Davis; C Davis; J Saadine; R B D'Agostino; D Dabelea; L Dolan; S Garg; J M Lawrence; C Pihoker; B L Rodriguez; B E Klein; R Klein; R A Bell; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: - ISSN: 1464-5491 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. |
Affiliation:
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Department of Nutrition and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC Centers for Disease Control and Prevention, Atlanta, GA Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO Department of Pediatric Endocrinology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, NC Department of Research and Evaluation, Kaiser Permanente, Southern California, Pasadena, CA Department of Pediatric Endocrinology and Diabetes, Children's Hospital and Regional Medical Center, Seattle, WA John A. Burns School of Medicine University of Hawai at Manoa, Honolulu, HI Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA. |
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