| Diabetic retinopathy in African Americans with type 1 diabetes: The New Jersey 725: II. Risk factors. | |
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MedLine Citation:
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PMID: 10636423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether diabetic retinopathy in African Americans with type 1 diabetes is associated with the following 6 putative risk factors: duration of diabetes, glycemic control, systemic hypertension, renal disease, socioeconomic status, and male sex. METHODS: Patients in The New Jersey 725 study underwent detailed ocular evaluation, a structured clinical interview, blood pressure measurements, and assays of blood and urine samples. RESULTS: Glycemic control was poor; 89.8% of the patients had glycosylated hemoglobin values of more than 0.08. Renal disease and systemic hypertension were present in 49.8% and 34.3% of patients, respectively. Frequency and severity of retinopathy were significantly associated with longer duration of diabetes (P<.001). After adjusting for duration of diabetes and other confounding variables, on average, patients with total glycosylated hemoglobin values in the highest quartile were 3 times more likely to have any retinopathy than those in the lowest quartile; patients with renal disease, 3 times more likely to have any retinopathy and 10 times more likely to have proliferative retinopathy than patients without renal disease; and patients in the highest quartile of systolic sitting blood pressure, 3 times more likely to have proliferative retinopathy than patients in the lowest quartile. CONCLUSIONS: Risk factors for diabetic retinopathy in African Americans with type 1 diabetes include presence of renal disease, poor glycemic control, high systolic blood pressure, and long duration of diabetes. |
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Authors:
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M S Roy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of ophthalmology Volume: 118 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-01-18 Completed Date: 2000-01-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 105-15 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, University of Medicine and Dentistry, New Jersey Medical School, Newark 07103, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Continental Ancestry Group* Aged Aged, 80 and over Blood Glucose Blood Pressure Child Child, Preschool Cohort Studies Diabetes Mellitus, Type 1 / ethnology*, pathology Diabetic Retinopathy / ethnology*, pathology Female Humans Hypertension / ethnology Kidney Diseases / ethnology Male Middle Aged New Jersey / epidemiology Risk Factors Severity of Illness Index Sex Factors Social Class Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY 09860/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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