Document Detail


Diabetic retinopathy in African Americans with type 1 diabetes: The New Jersey 725: II. Risk factors.
MedLine Citation:
PMID:  10636423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether diabetic retinopathy in African Americans with type 1 diabetes is associated with the following 6 putative risk factors: duration of diabetes, glycemic control, systemic hypertension, renal disease, socioeconomic status, and male sex. METHODS: Patients in The New Jersey 725 study underwent detailed ocular evaluation, a structured clinical interview, blood pressure measurements, and assays of blood and urine samples. RESULTS: Glycemic control was poor; 89.8% of the patients had glycosylated hemoglobin values of more than 0.08. Renal disease and systemic hypertension were present in 49.8% and 34.3% of patients, respectively. Frequency and severity of retinopathy were significantly associated with longer duration of diabetes (P<.001). After adjusting for duration of diabetes and other confounding variables, on average, patients with total glycosylated hemoglobin values in the highest quartile were 3 times more likely to have any retinopathy than those in the lowest quartile; patients with renal disease, 3 times more likely to have any retinopathy and 10 times more likely to have proliferative retinopathy than patients without renal disease; and patients in the highest quartile of systolic sitting blood pressure, 3 times more likely to have proliferative retinopathy than patients in the lowest quartile. CONCLUSIONS: Risk factors for diabetic retinopathy in African Americans with type 1 diabetes include presence of renal disease, poor glycemic control, high systolic blood pressure, and long duration of diabetes.
Authors:
M S Roy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  118     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-18     Completed Date:  2000-01-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-15     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmology, University of Medicine and Dentistry, New Jersey Medical School, Newark 07103, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Continental Ancestry Group*
Aged
Aged, 80 and over
Blood Glucose
Blood Pressure
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1 / ethnology*,  pathology
Diabetic Retinopathy / ethnology*,  pathology
Female
Humans
Hypertension / ethnology
Kidney Diseases / ethnology
Male
Middle Aged
New Jersey / epidemiology
Risk Factors
Severity of Illness Index
Sex Factors
Social Class
Time Factors
Grant Support
ID/Acronym/Agency:
R01 EY 09860/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose

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