| Diabetic neuropathy in elderly Type 2 diabetic patients: effects of insulin treatment. | |
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MedLine Citation:
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PMID: 9858106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To study the occurrence of diabetic neuropathy and the effect of insulin treatment in elderly Type 2 diabetic patients. MATERIAL AND METHODS: In 38 patients and 20 controls symptoms and neurophysiological examinations including electroneurography, vibration perception and temperature discrimination thresholds were investigated. Patients were randomized to insulin (n = 18) or sulfonylurea (n = 16) treatment and were re-investigated after 1 year. RESULTS: Neuropathy was present in 21/38 patients (56%). It was asymptomatic in 17/38 (45%) and symptomatic in 4/38 (11%). The occurrence of neuropathy was less common in healthy controls, 3/20 (15%) (P < 0.01). Temperature discrimination thresholds was the test that most often revealed pathology. The metabolic control after 1 year was significantly improved in the insulin treated group and unchanged in the sulfonylurea treated group. There were no changes as regards occurrence of neuropathy between or within the two treatment groups after 1 year. CONCLUSION: Diabetic neuropathy is common among elderly Type 2 diabetic patients. It is mostly asymptomatic. Improvement was not seen after 1 year of insulin treatment. |
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Authors:
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J Tovi; E Svanborg; B Y Nilsson; P Engfeldt |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 98 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-02-26 Completed Date: 1999-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 346-53 Citation Subset: IM |
Affiliation:
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Family Medicine Stockholm, Karolinska Institutet, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Diabetes Mellitus, Type 2 / complications* Diabetic Neuropathies / drug therapy*, etiology, pathology Female Humans Hypoglycemic Agents / therapeutic use* Insulin / therapeutic use* Male Temperature Sense / physiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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