Document Detail

Diabetic late complications: will aldose reductase inhibitors or inhibitors of advanced glycosylation endproduct formation hold promise?
MedLine Citation:
PMID:  7599349     Owner:  NLM     Status:  MEDLINE    
Patients suffering from the severe complications associated with both insulin- (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM): nephropathy, retinopathy, neuropathy, and atherosclerosis are still largely left without a prospect of an efficient treatment. This is the case even if it has been assumed for decades and now finally proved by the results from the Diabetes Control and Complications Trial (DCCT) that hyperglycemia is the single main cause of these complications. Improved glycemic control as a result of intensive insulin treatment has the potential to reduce the incidence and progression of complications, but implementation and monitoring of improved glycemic control in all groups of IDDM and NIDDM patients in different communities will be difficult and expensive. Results from the recently terminated DCCT have shown that even with intensive insulin treatment, there will be a significant burden of complications on the diabetic population. It will, therefore, still be of immense importance for the long-term quality of life for the diabetic patient that additional possibilities are developed for prevention and intervention against diabetic complications. Almost two decades of research, animal model testing, and clinical trials have been conducted on various efficient aldose reductase inhibitors. Now the concept of inhibition of formation of advanced glycosylation endproducts on proteins and lipids resulting from extra- and intracellular hyperglycemia is entering the scene as an alternative or perhaps supplementary approach to reduce the occurrence of diabetic complications. An overview of the results from these two fields of research and associated drug-development programs will be presented along with thoughts on possible future developments.
E Boel; J Selmer; H J Flodgaard; T Jensen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of diabetes and its complications     Volume:  9     ISSN:  1056-8727     ISO Abbreviation:  J. Diabetes Complicat.     Publication Date:    1995 Apr-Jun
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204583     Medline TA:  J Diabetes Complications     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  104-29     Citation Subset:  IM    
Novo Nordisk, Bagsvaerd, Denmark.
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MeSH Terms
Aldehyde Reductase / antagonists & inhibitors*
Arteriosclerosis / drug therapy
Clinical Trials as Topic
Diabetes Mellitus, Type 1 / drug therapy,  physiopathology*
Diabetes Mellitus, Type 2 / drug therapy,  physiopathology*
Diabetic Angiopathies / drug therapy*
Diabetic Nephropathies / drug therapy*
Diabetic Neuropathies / drug therapy*
Diabetic Retinopathy / drug therapy*
Glycosylation End Products, Advanced / antagonists & inhibitors*
Insulin / therapeutic use
Reg. No./Substance:
0/Glycosylation End Products, Advanced; 11061-68-0/Insulin; EC Reductase

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