Document Detail


Diabetic gastroparesis: diagnosis and management.
MedLine Citation:
PMID:  19496627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastric emptying is frequently abnormal in patients with long-standing type 1 and type 2 diabetes mellitus. Symptoms commonly associated with disordered gastric emptying include nausea, vomiting, bloating and epigastric pain, while patients are also at risk of malnutrition, weight loss, impaired drug absorption, disordered glycaemic control and poor quality of life. Although often attributed to the presence of irreversible autonomic neuropathy, acute hyperglycaemia represents a potentially reversible cause of gastric dysfunction in diabetes. Scintigraphy represents the gold standard for measuring gastric emptying. The management of diabetic gastroparesis is less than optimal, partly because the pathogenesis has not been clearly defined. Treatment approaches include dietary modification and optimization of glycaemia, and the use of prokinetic drugs, while novel therapies such as gastric electrical stimulation are the subject of ongoing investigation.
Authors:
Jing Ma; Christopher K Rayner; Karen L Jones; Michael Horowitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Drugs     Volume:  69     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-05     Completed Date:  2009-11-04     Revised Date:  2010-01-19    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  971-86     Citation Subset:  IM    
Affiliation:
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Type 1 / complications*
Diabetes Mellitus, Type 2 / complications*
Gastric Emptying
Gastroparesis / diagnosis,  etiology,  therapy*
Humans
Hyperglycemia / complications,  physiopathology
Prevalence
Radionuclide Imaging / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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