Document Detail


Diabetic embryopathy: a role for the epigenome?
MedLine Citation:
PMID:  21538816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Embryonic development under adverse conditions, such as maternal diabetes or obesity during pregnancy, constitutes a major risk factor for birth defects, as well as for long-term health consequences and disease susceptibility in the offspring. While contributions from epigenetic changes have been invoked previously to explain the long-term changes in terms of developmental programming, we here review how maternal metabolism may directly affect the embryonic epigenome in relationship to teratogenic processes. We consider four epigenetic modalities--DNA methylation, non-coding RNA, transcription factors, and histone modifications--and their contribution to epigenetic memory, and discuss how epigenomic changes may mediate the altered control of embryonic gene expression brought about by maternal diabetes. In combination, the epigenomic modalities serve to define transcription-permissive domains of the genome, resulting in distinct epigenomic landscapes in different developmental cell types. We evaluate experimental approaches to characterize the epigenome in adverse pregnancy conditions, highlighting the role of next-generation sequencing on the technological side, while emphasizing the necessity to study defined cell populations in terms of biologic impact. Finally, we outline the challenges in moving from findings that correlate epigenomics to developmental phenotypes to scenarios that establish teratogenic causality.
Authors:
J Michael Salbaum; Claudia Kappen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-05-02
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  91     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-08     Completed Date:  2012-01-30     Revised Date:  2013-09-13    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  770-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. michael.salbaum@pbrc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes, Gestational*
Disease Susceptibility
Embryo, Mammalian / pathology*
Epigenesis, Genetic / genetics*
Female
Gene Expression Regulation, Developmental*
Humans
Pregnancy
Pregnancy in Diabetics*
Grant Support
ID/Acronym/Agency:
HD055528/HD/NICHD NIH HHS; HD37804/HD/NICHD NIH HHS; R01 HD037804/HD/NICHD NIH HHS; R01 HD037804-10/HD/NICHD NIH HHS; R01 HD055528-05/HD/NICHD NIH HHS
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