Document Detail


Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies.
MedLine Citation:
PMID:  21057575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diabetic cardiomyopathy (DCM), although a distinct clinical entity, is also a part of the diabetic atherosclerosis process. It may be independent of the coexistence of ischemic heart disease, hypertension, or other macrovascular complications. Its pathological substrate is characterized by the presence of myocardial damage, reactive hypertrophy, and intermediary fibrosis, structural and functional changes of the small coronary vessels, disturbance of the management of the metabolic cardiovascular load, and cardiac autonomic neuropathy. These alterations make the diabetic heart susceptible to ischemia and less able to recover from an ischemic attack. Arterial hypertension frequently coexists with and exacerbates cardiac functioning, leading to the premature appearance of heart failure. Classical and newer echocardiographic methods are available for early diagnosis. Currently, there is no specific treatment for DCM; targeting its pathophysiological substrate by effective risk management protects the myocardium from further damage and has a recognized primary role in its prevention. Its pathophysiological substrate is also the objective for the new therapies and alternative remedies.
Authors:
Christina Voulgari; Dimitrios Papadogiannis; Nicholas Tentolouris
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-21
Journal Detail:
Title:  Vascular health and risk management     Volume:  6     ISSN:  1178-2048     ISO Abbreviation:  Vasc Health Risk Manag     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-08     Completed Date:  2010-12-03     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101273479     Medline TA:  Vasc Health Risk Manag     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  883-903     Citation Subset:  IM    
Affiliation:
First Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece. c_v_24@yahoo.gr
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / diagnosis,  etiology*,  physiopathology,  therapy
Diabetes Complications / diagnosis,  physiopathology*,  therapy
Echocardiography
Humans
Hyperglycemia / complications,  physiopathology
Hypertension / complications,  prevention & control
Insulin Resistance / physiology
Metabolic Syndrome X / complications,  physiopathology
Muscle Cells / physiology*
Risk Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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