Document Detail

Diabetic medications in pregnancy.
MedLine Citation:
PMID:  19925389     Owner:  NLM     Status:  MEDLINE    
All forms of diabetes are increasing in prevalence, but with the advent of the obesity epidemic, we now face the prospect of an increasing number of women conceiving whilst taking traditional oral antidiabetic agents (OADs). This is also further complicated by the availability of new incretin-based therapies, the dipeptidylpeptidase-4 (DPP-IV) inhibitors and glucagon-like-1 receptor (GLP-1R) analogues. Original concerns regarding the use of such OADs have meant that diet control and insulin has been the mainstay of treatment for hyperglycaemia during pregnancy. However, recent NICE guidelines have suggested a role for oral antidiabetic agents. Safety is of paramount concern, especially in pregnancy, and this review will discuss the evidence to date.
James Young; Aresh Anwar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current diabetes reviews     Volume:  5     ISSN:  1875-6417     ISO Abbreviation:  Curr Diabetes Rev     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101253260     Medline TA:  Curr Diabetes Rev     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  252-8     Citation Subset:  IM    
University Hospital Birmingham, Queen Elizabeth Hospital, Department of Endocrinology, Edgbaston, Birmingham B15 2th, UK.
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MeSH Terms
Antigens, CD26 / antagonists & inhibitors
Diabetes, Gestational / drug therapy*
Enzyme Inhibitors / administration & dosage*,  adverse effects
Glucagon-Like Peptide 1 / analogs & derivatives*
Hypoglycemic Agents / administration & dosage*,  adverse effects
Thiazolidinediones / therapeutic use*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Hypoglycemic Agents; 0/Thiazolidinediones; 89750-14-1/Glucagon-Like Peptide 1; EC, CD26; EC protein, human

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