| Diabetic ketoacidosis with concurrent pancreatitis, pancreatic β islet cell tumor, and adrenal disease in an obese ferret (Mustela putorius furo). | |
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MedLine Citation:
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PMID: 21838985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 5.5-y-old spayed female ferret (Mustela putorius furo) with a history of adrenal disease, respiratory disease, and chronic obesity was evaluated for progressive lethargy and ataxia, diminished appetite, and possible polyuria and polydipsia. Physical examination revealed obesity, lethargy, tachypnea, dyspnea, a pendulous abdomen, significant weakness and ataxia of the hindlimbs, prolonged skin tenting, and mild tail-tip alopecia. Clinicopathologic analysis revealed severe hyperglycemia, azotemia, an increased anion gap, glucosuria, ketonuria, proteinuria, and hematuria. Abdominal ultrasonography showed hyperechoic hepatomegaly, bilateral adrenomegaly, splenic nodules, mild peritoneal effusion, and thickened and mildly hypoechoic limbs of the pancreas with surrounding hyperechoic mesentery. Fine-needle aspirates of the liver were highly suggestive of hepatic lipidosis. In light of a diagnosis of concurrent diabetic ketoacidosis and pancreatitis, the ferret was treated with fluid therapy, regular and long-acting insulin administration, and pain medication. However, electrolyte derangements, metabolic acidosis, dyspnea, and the clinical appearance of the ferret progressively worsened despite treatment, and euthanasia was elected. Necropsy revealed severe hepatic lipidosis, severe suppurative pancreatitis and vacuolar degeneration of pancreatic islet cells, a pancreatic β islet cell tumor, bilateral adrenal cortical adenomas, and myocardial fibrosis. To our knowledge, this case represents the first report of concurrent diabetes mellitus, pancreatitis, pancreatic β islet cell tumor (insulinoma), and adrenal disease in a domestic ferret. The simultaneous existence of 3 endocrine diseases, pancreatitis, and their associated complications is a unique and clinically challenging situation. |
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Authors:
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Kristen A Phair; James W Carpenter; Thomas Schermerhorn; Chanran K Ganta; Brad M DeBey |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the American Association for Laboratory Animal Science : JAALAS Volume: 50 ISSN: 1559-6109 ISO Abbreviation: J. Am. Assoc. Lab. Anim. Sci. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-08-15 Completed Date: 2011-12-12 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 101269489 Medline TA: J Am Assoc Lab Anim Sci Country: United States |
Other Details:
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Languages: eng Pagination: 531-5 Citation Subset: IM |
Copyright Information:
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Copyright 2011 by the American Association for Laboratory Animal Science |
Affiliation:
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Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA. kaphair@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Diseases
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complications,
pathology,
veterinary* Animals Blood Chemical Analysis / veterinary Diabetic Ketoacidosis / complications, drug therapy, pathology, veterinary* Female Ferrets* Fluid Therapy / veterinary Insulin / therapeutic use Insulinoma / complications, pathology, veterinary* Obesity / complications, pathology, veterinary* Pancreatic Neoplasms / complications, pathology, veterinary* Pancreatitis / complications, drug therapy, pathology, veterinary* Urinalysis / veterinary Viscera / ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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