| Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against Ischemia/Reperfusion Injury. | |
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MedLine Citation:
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PMID: 21822424 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Ischemic preconditioning (IPC) or postconditioning (Ipost) is proved to efficiently prevent ischemia/reperfusion injuries. Mortality of diabetic patients with acute myocardial infarction was found to be 2-6 folds higher than that of non-diabetic patients with same myocardial infarction, which may be in part due to diabetic inhibition of IPC- and Ipost-mediated protective mechanisms. Both IPC- and Ipost-mediated myocardial protection is predominantly mediated by stimulating PI3K/Akt and associated GSK-3β pathway while diabetes-mediated pathogenic effects are found to be mediated by inhibiting PI3K/Akt and associated GSK-3β pathway. Therefore, this review briefly introduced the general features of IPC- and Ipost-mediated myocardial protection and the general pathogenic effects of diabetes on the myocardium. We have collected experimental evidence that indicates the diabetic inhibition of IPC- and Ipost-mediated myocardial protection. Increasing evidence implies that diabetic inhibition of IPC- and Ipost-mediated myocardial protection may be mediated by inhibiting PI3K/Akt and associated GSK-3β pathway. Therefore any strategy to activate PI3K/Akt and associated GSK-3β pathway to release the diabetic inhibition of both IPC and Ipost-mediated myocardial protection may provide the protective effect against ischemia/reperfusion injuries. |
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Authors:
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Xia Yin; Yang Zheng; Xujie Zhai; Xin Zhao; Lu Cai |
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Publication Detail:
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Type: Journal Article Date: 2011-08-01 |
Journal Detail:
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Title: Experimental diabetes research Volume: 2012 ISSN: 1687-5303 ISO Abbreviation: Exp Diabetes Res Publication Date: 2012 |
Date Detail:
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Created Date: 2011-08-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274844 Medline TA: Exp Diabetes Res Country: United States |
Other Details:
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Languages: eng Pagination: 198048 Citation Subset: IM |
Affiliation:
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The Cardiovascular Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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