| Diabetes is a risk factor for pulmonary tuberculosis: a case-control study from Mwanza, Tanzania. | |
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MedLine Citation:
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PMID: 21912626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Diabetes and TB are associated, and diabetes is increasingly common in low-income countries where tuberculosis (TB) is highly endemic. However, the role of diabetes for TB has not been assessed in populations where HIV is prevalent. METHODS: A case-control study was conducted in an urban population in Tanzania among culture-confirmed pulmonary TB patients and non-TB neighbourhood controls. Participants were tested for diabetes according to WHO guidelines and serum concentrations of acute phase reactants were measured. The association between diabetes and TB, and the role of HIV as an effect modifier, were examined using logistic regression. Since blood glucose levels increase during the acute phase response, we adjusted for elevated serum acute phase reactants. RESULTS: Among 803 cases and 350 controls the mean (SD) age was 34.8 (11.9) and 33.8 (12.0) years, and the prevalence of diabetes was 16.7% (95% CI: 14.2; 19.4) and 9.4% (6.6; 13.0), respectively. Diabetes was associated with TB (OR 2.2, 95% CI: 1.5; 3.4, p<0.001). However, the association depended on HIV status (interaction, p = 0.01) due to a stronger association among HIV uninfected (OR 4.2, 95% CI: 1.5; 11.6, p = 0.01) compared to HIV infected (OR 0.1, 95% CI: 0.01; 1.8, p = 0.13) after adjusting for age, sex, demographic factors and elevated serum acute phase reactants. CONCLUSION: Diabetes is a risk factor for TB in HIV uninfected, whereas the association in HIV infected patients needs further study. The increasing diabetes prevalence may be a threat to TB control. |
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Authors:
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Daniel Faurholt-Jepsen; Nyagosya Range; George Praygod; Kidola Jeremiah; Maria Faurholt-Jepsen; Martine Grosos Aabye; John Changalucha; Dirk Lund Christensen; Christian Bressen Pipper; Henrik Krarup; Daniel Rinse Witte; Aase Bengaard Andersen; Henrik Friis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-08-30 |
Journal Detail:
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Title: PloS one Volume: 6 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-13 Completed Date: 2011-12-23 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 101285081 Medline TA: PLoS One Country: United States |
Other Details:
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Languages: eng Pagination: e24215 Citation Subset: IM |
Affiliation:
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Department of Human Nutrition, University of Copenhagen, Frederiksberg, Denmark. dfa@life.ku.dk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Diabetes Complications / epidemiology*, virology Female HIV-1 / pathogenicity HIV-2 / pathogenicity Humans Male Risk Factors Tanzania / epidemiology Tuberculosis, Pulmonary / epidemiology*, etiology*, virology |
| Comments/Corrections | |
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