Document Detail


Diabetes and risk of esophageal and gastric adenocarcinomas.
MedLine Citation:
PMID:  22161620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastric cardia and distal gastric adenocarcinomas (DGAs). This analysis included patients with esophageal adenocarcinoma (EA) (n = 209), gastric cardia adenocarcinoma (GCA) (n = 257) and DGA (n = 382), and 1,309 control participants from a population-based case-control study conducted in Los Angeles County. The study included non-Hispanic whites, African Americans, Hispanics and Asian Americans. The association of diabetes with the three tumor types was estimated using polytomous logistic regression. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated. Nine percent of control participants and 13% of the case patients reported a history of diabetes. After adjustment for age, gender, race, birthplace, education, cigarette smoking status and body mass index, diabetes was associated with an increased risk of EA (OR, 1.48; 95% CI, 0.94-2.32; p = 0.089) and DGA (OR, 1.47; 95% CI, 1.01-2.15; p = 0.045), but was not associated with risk of GCA (OR, 0.96; 95% CI, 0.59-1.55; p = 0.87). However, the association between diabetes and risk of DGA was statistically significant only among patients for whom we interviewed their next of kin. Our study further investigated the association between diabetes and adenocarcinomas of the esophagus and distal stomach.
Authors:
Xuejuan Jiang; Leslie Bernstein; Chiu-Chen Tseng; Anna H Wu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-01-11
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  131     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2013-03-11     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1417-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 UICC.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / etiology*
Adult
Aged
Cardia
Case-Control Studies
Diabetes Complications / etiology*
Esophageal Neoplasms / etiology*
Female
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Risk
Stomach Neoplasms / etiology*
Grant Support
ID/Acronym/Agency:
5P30 ES07048/ES/NIEHS NIH HHS; CA59636/CA/NCI NIH HHS; N01CN25403/CN/NCI NIH HHS; R01 CA059636/CA/NCI NIH HHS; R01 CA059636-05/CA/NCI NIH HHS
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