| Diabetes, related conditions, and dementia. | |
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MedLine Citation:
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PMID: 20888602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This manuscript provides a brief review of the epidemiologic evidence linking type 2 diabetes (T2D) and its precursor conditions, elevated adiposity and hyperinsulinemia, to dementia. Elevated adiposity in middle age is related to a higher risk of dementia but the data on this association in old age is conflicting. Hyperinsulinemia, a consequence of higher adiposity and insulin resistance is also related to a higher risk of dementia, including late onset Alzheimer's disease (LOAD). Studies have consistently shown a relation of T2D with higher dementia risk, but the associations are stronger for vascular dementia compared to LOAD. One implication of these associations is that strategies used to prevent T2D can be used to prevent dementia. Several studies in the prevention and treatment of T2D are currently measuring cognitive outcomes and will provide information on whether T2D treatment and prevention can prevent cognitive decline and dementia. |
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Authors:
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José A Luchsinger |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 299 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-03-16 Revised Date: 2011-12-19 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 35-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010. Published by Elsevier B.V. |
Affiliation:
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Division of General Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. jal94@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity* Aged Aged, 80 and over Dementia / etiology* Diabetes Mellitus, Type 2 / complications* Humans Metabolic Syndrome X / complications* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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AG026413/AG/NIA NIH HHS; AG07232/AG/NIA NIH HHS; P01 AG007232-200009/AG/NIA NIH HHS; P60 MD000206-070002/MD/NIMHD NIH HHS; P60 MD00206/MD/NIMHD NIH HHS; R01 AG026413-03/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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