| Diabetes, nephropathy, and the renin system. | |
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MedLine Citation:
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PMID: 16601578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blockade of the renin-angiotensin system has become crucial in the management of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus, especially in patients who are at risk of nephropathy. In this review, we address the issue of why the renin system and its blockade are so important. As in many complex processes, diabetic nephropathy reflects an interaction between genetic factors and environmental factors. Recent research has uncovered a number of environmental factors; control of these factors should contribute to improved management. The renin system is important in patients with diabetes mellitus because so many relevant factors converge on the intrarenal renin system. |
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Authors:
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Norman K Hollenberg |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 24 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-04-07 Completed Date: 2006-07-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: England |
Other Details:
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Languages: eng Pagination: S81-7 Citation Subset: IM |
Affiliation:
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Department of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. djpagecapo@rics.bwh.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II Type 1 Receptor Blockers
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pharmacology Angiotensin-Converting Enzyme Inhibitors / pharmacology Animals Diabetes Mellitus / physiopathology* Diabetic Nephropathies / ethnology, etiology* Female Glomerular Filtration Rate / drug effects Humans Kidney / drug effects, physiopathology Male Obesity / complications Renal Plasma Flow / drug effects Renin-Angiotensin System / physiology* Risk Factors Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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