| Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis. | |
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MedLine Citation:
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PMID: 21898753 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The studies of diabetes and hepatocellular carcinoma (HCC) reported inconsistent findings. This meta-analysis was conducted to examine the association between diabetes and risk of HCC. METHODS: Studies were identified by searching PUBMED and MEDLINE database up to February 2011. Pooled risk estimates were calculated using the random-effects model. Potential sources of heterogeneity were explored by subgroup analyses. RESULTS: A total of 17 case-control studies and 32 cohort studies were included in the meta-analysis. The combined risk estimate of all studies showed a statistically significant increased risk of HCC incidence among diabetic individuals (RR = 2.31, 95% CI: 1.87, 2.84). The pooled risk estimate of 17 case-control studies (OR = 2.40, 95% CI: 1.85, 3.11) was slightly higher than that from 25 cohort studies (RR = 2.23, 95% CI: 1.68, 2.96). Metformin treatment was found with potentially protective effects against risk of HCC. On the contrary, long duration of diabetes and sulfonylureas or insulin treatment could increase HCC risk. Also meta-analysis of 7 cohort studies found a statistically significant increased risk of HCC mortality (RR = 2.43, 95% CI: 1.66, 3.55) for individuals with (versus without) diabetes. CONCLUSIONS: This meta-analysis shows that diabetes is associated with moderately increased risk of HCC incidence, as well as HCC mortality. Considering the rapidly increasing prevalence of diabetes mellitus, the study underlines the need for cancer prevention in diabetic individuals. Further investigation is needed to focus on the potential mechanism for the pathogenesis of HCC, and the link between HCC and different types, severity, treatment and duration of diabetes. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Ping Wang; Donghong Kang; Wei Cao; Yan Wang; Zhiwen Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-5 |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: - ISSN: 1520-7560 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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School of Medicine, Shandong University, Jinan City, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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