| Diabetes mellitus and risk of gastric cancer: a systematic review and meta-analysis of observational studies. | |
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MedLine Citation:
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PMID: 21934509 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: Increasing evidence suggests that a history of diabetes may be involved in the development of various sites of cancer. However, the association of diabetes and risk of gastric cancer (GC) remains unclear. METHODS: We identified studies by a literature search of MEDLINE (from 1 January 1966), Web of Science (from 1 January 1994), and EMBASE (from 1 January 1974 through 31 May 2011), and by searching the reference lists of pertinent articles. All data were extracted independently by two investigators using a standardized data abstraction tool. Summary relative risks (SRRs) with 95% confidence intervals (CIs) were calculated with a random-effects model. Between-study heterogeneity was assessed using the Cochran's Q and I statistics. RESULTS: A total of 21 studies (four case-control studies, 17 cohort studies) were included in this meta-analysis. Analysis of these 21 studies found that compared with nondiabetic individuals, diabetic individuals had a similar risk of GC (SRRs, 1.09; 95% CI: 0.98-1.22). There was strong evidence of heterogeneity among these studies (P<0.001, I=81.2%). A subgrouped analysis found that diabetic women had 18% increased risk of GC (SRRs, 1.18; 95% CI: 1.01-1.39), whereas it was not the case with diabetic men. No significant public bias was found in this study. CONCLUSION: These findings of this systematic review indicate that compared with nondiabetic individuals, diabetic women have an 18% increased risk of GC development. However, diabetic men have a similar risk of GC. |
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Authors:
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Zhenming Ge; Qiwen Ben; Junbo Qian; Yamin Wang; Yuming Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-19 |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: - ISSN: 1473-5687 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aDepartment of Gastroenterology, The First People's Hospital of Nantong, Jiangsu bDepartment of Gastroenterology, Changhai Hospital of Second Military Medical University, Shanghai, China. |
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