Document Detail


Diabetes mellitus: an opportunity for therapy with stem cells?
MedLine Citation:
PMID:  18462060     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In both Type 1 and 2 diabetes, insufficient numbers of insulin-producing beta-cells are a major cause of defective control of blood glucose and its complications. Restoration of damaged beta-cells by endocrine pancreas regeneration would be an ideal therapeutic option. The possibility of generating insulin-secreting cells with adult pancreatic stem or progenitor cells has been investigated extensively. The conversion of differentiated cells such as hepatocytes into beta-cells is being attempted using molecular insights into the transcriptional make-up of beta-cells. Additionally, the enhanced proliferation of beta-cells in vivo or in vitro is being pursued as a strategy for regenerative medicine for diabetes. Advances have also been made in directing the differentiation of embryonic stem cells into beta-cells. Although progress is encouraging, major gaps in our understanding of developmental biology of the pancreas and adult beta-cell dynamics remain to be bridged before a therapeutic application is made possible.
Authors:
Valeria Sordi; Federico Bertuzzi; Lorenzo Piemonti
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Regenerative medicine     Volume:  3     ISSN:  1746-076X     ISO Abbreviation:  Regen Med     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-08     Completed Date:  2008-08-07     Revised Date:  2011-11-24    
Medline Journal Info:
Nlm Unique ID:  101278116     Medline TA:  Regen Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-97     Citation Subset:  IM    
Affiliation:
Laboratory of Experimental Surgery, San Raffaele Scientific Institute, via Olgettina 60, 20132 Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Cell Differentiation
Diabetes Mellitus / metabolism*,  therapy*
Disease Models, Animal
Humans
Insulin / metabolism
Insulin-Secreting Cells / cytology
Mice
Models, Biological
Regenerative Medicine / methods
Stem Cell Transplantation / methods*
Stem Cells / cytology
Treatment Outcome
Grant Support
ID/Acronym/Agency:
JT01Y01//Telethon
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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