Document Detail

Diabetes mellitus and the incidence and mortality of colorectal cancer: a meta-analysis of 24 cohort studies.
MedLine Citation:
PMID:  23046351     Owner:  NLM     Status:  MEDLINE    
AIM: The incidence and mortality of colorectal cancer (CRC) were quantified in persons with and without diabetes mellitus (DM).
METHOD: Medline and Embase were searched for articles published before July 2010. Cohort studies that evaluated incidence and mortality of DM and CRC were included. The initial search identified 1887 titles, of which 24 articles met the inclusion criteria. We defined the relative risk (RR) as the metric of choice; 95% confidence intervals (CIs) were calculated with a random-effects model.
RESULTS: There was an increase in the RR of developing CRC in persons with DM compared with those without DM (RR 1.28; 95% CI 1.19-1.39), without heterogeneity between studies (P(heterogeneity) = 0.13). The association between duration of DM and CRC incidence was stronger in the 11-15-year group (RR 1.51; 95% CI 1.12-2.03) than in the <10-year group (RR 1.05; 95% CI 0.90-1.22) and the >15-year group (RR 1.25; 95% CI 0.80-1.94), and there was significant heterogeneity among subgroups (P(heterogeneity) = 0.01). In studies reporting standardized incidence ratios (SIRs), there was an increased incidence of CRC with DM (RR 1.27; 95% CI 1.14-1.42; P(heterogeneity) = 0.09), and the association was stronger among men (RR 1.47; 95% CI 1.15-1.86) than women (RR 1.08; 95% CI 1.00-1.17); there was significant heterogeneity among gender (P(heterogeneity) = 0.01).
CONCLUSION: This meta-analysis suggests that individuals with DM have a significant increase in risk of developing CRC.
W Luo; Y Cao; C Liao; F Gao
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  14     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-03-19     Revised Date:  2013-10-11    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  1307-12     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland.
Center of Evidence Based Medicine, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
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MeSH Terms
Cohort Studies
Colorectal Neoplasms / epidemiology,  etiology*,  mortality
Confidence Intervals
Diabetes Complications*
Diabetes Mellitus, Type 2 / complications*
Comment In:
Colorectal Dis. 2013 Aug;15(8):1045   [PMID:  23663655 ]

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