Document Detail


Diabetes mellitus and bladder cancer--an epidemiological relationship?
MedLine Citation:
PMID:  12704444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An epidemiological association between diabetes mellitus and transitional cell carcinoma of the bladder has been proposed. This study looked retrospectively at 125 patients with transitional cell carcinoma of the bladder as a study group and 80 other hospital patients with conditions not specifically associated with diabetes mellitus as a control group. Diabetic patients had an increased, significant odds ratio for bladder cancer compared with non diabetics even after adjustment for smoking and age [OR: 2.69 p=0.049 (95% CI 1.006-7.194)] A history of smoking OR 2.16 p=0.013 (95% C.I. 1.175-3.964) is a significant independent association with transitional cell carcinoma of the bladder as is age: p=0.001 OR 1.07. We propose potential pathogenic pathways for transitional cell carcinoma of the bladder in diabetic patients based on altered integrin and cadherin distribution in urothelial cells in diabetic patients. A larger study is planned to confirm an association between diabetes mellitus and transitional cell carcinoma of the bladder.
Authors:
Yeung Ng; I Husain; N Waterfall
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Publication Detail:
Type:  Journal Article     Date:  2003-04-18
Journal Detail:
Title:  Pathology oncology research : POR     Volume:  9     ISSN:  1219-4956     ISO Abbreviation:  Pathol. Oncol. Res.     Publication Date:  2003  
Date Detail:
Created Date:  2003-04-21     Completed Date:  2004-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9706087     Medline TA:  Pathol Oncol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  30-1     Citation Subset:  IM    
Affiliation:
Department of Surgery and Molecular Oncology, University of Dundee, UK. y.ng@dundee.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Carcinoma, Transitional Cell / etiology,  pathology
Case-Control Studies
Comorbidity
Diabetes Complications
Diabetes Mellitus / epidemiology*
Female
Humans
Male
Middle Aged
Odds Ratio
Retrospective Studies
Risk Factors
Smoking
Urinary Bladder Neoplasms / complications*,  epidemiology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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