Document Detail

Diabetes insipidus, Sheehan's syndrome and pregnancy.
MedLine Citation:
PMID:  9578279     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the role of vasopressin in osmoregulation in two successive pregnancies in a woman with Sheehan's syndrome. STUDY DESIGN: Diabetes insipidus (DI) became manifest during two pregnancies in a woman with postpartum hypopituitarism. RESULTS: Water deprivation-vasopressin administration tests demonstrated partial central DI, corrected with vasopressin in week 12, but only with desmopressin in the third trimester, when placental cystylamino peptidase (vasopressinase) contributes to the severity of the DI. CONCLUSION: If DI occurs during pregnancy it may be the first manifestation of a latent central DI, which is often idiopathic, but rarely the first symptom of a pituitary or hypothalamic abnormality. It may also be part of Sheehan's syndrome.
J W Briet
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  77     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-11     Completed Date:  1998-06-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  201-3     Citation Subset:  IM    
Department of obstetrics and gynaecology, Geertruiden Hospital, Deventer, Netherlands.
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MeSH Terms
Cystinyl Aminopeptidase / metabolism
Deamino Arginine Vasopressin / administration & dosage,  therapeutic use
Diabetes Insipidus / complications,  diagnosis*,  drug therapy
Gestational Age
Hypopituitarism / complications,  diagnosis*
Osmolar Concentration
Ovulation Induction
Placenta / enzymology
Pregnancy Complications*
Vasopressins / diagnostic use
Water Deprivation
Reg. No./Substance:
11000-17-2/Vasopressins; 16679-58-6/Deamino Arginine Vasopressin; EC Aminopeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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