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Diabetes influences cardiac extracellular matrix remodeling after myocardial infarction and subsequent development of cardiac dysfunction.
MedLine Citation:
PMID:  22862852     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study was conducted to examine the influence of acute streptozotocin-induced diabetes on cardiac remodeling and function in mice subjected to myocardial infarction (MI) by coronary artery ligation. Echocardiography analysis indicated that diabetes induced deleterious cardiac functional changes as demonstrated by the negative differences of ejection fraction, fractional shortening, stroke volume, cardiac output and left ventricular volume 24 hours after MI. Temporal analysis for up to 2 weeks post-MI showed higher mortality in diabetic animals due to cardiac wall rupture. To examine extracellular matrix remodeling we used fluorescent molecular tomography to conduct temporal studies and observed that total matrix metalloproteinase (MMP) activity in hearts was higher in diabetic animals at 7 and 14 days post-MI, which correlated well with the degree of collagen deposition in the infarct area visualized by scanning electron microscopy. Gene arrays indicated temporal changes in expression of distinct MMP isoforms after 1 or 2 weeks post-MI, particularly in diabetic mice. Temporal changes in cardiac performance were observed, with a trend of exaggerated dysfunction in diabetic mice up to 14 days post-MI. Decreased radial and longitudinal systolic and diastolic strain rates were observed over 14 days post-MI, and there was a trend toward altered strain rates in diabetic mouse hearts with dyssynchronous wall motion clearly evident. This correlated with increased collagen deposition in remote areas of these infarcted hearts indicated by Masson's trichrome staining. In summary, temporal changes in extracellular matrix remodeling correlated with exaggerated cardiac dysfunction in diabetic mice after MI. © 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
Authors:
Megumi Eguchi; Guoxiong Xu; Ren-Ke Li; Gary Sweeney
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-4
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  -     ISSN:  1582-4934     ISO Abbreviation:  J. Cell. Mol. Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
Affiliation:
Department of Biology, York University, Toronto, Ontario, Canada; Institut Pasteur Korea, Seoul, South Korea.
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