| Diabetes-induced changes in monoamine concentrations of rat hypothalamic nuclei. | |
| | |
MedLine Citation:
|
PMID: 2438007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Streptozotocin-induced diabetes produced marked alterations of monoamine concentrations in several hypothalamic nuclei of male and female rats. Norepinephrine (NE) concentrations were significantly elevated in the median eminence (ME), supraoptic nucleus (SON) and periventricular nucleus (PEVN) in both sexes of diabetic rats. NE concentrations in the suprachiasmatic nucleus (SCN) and ventromedial nucleus (VMN) of male and female diabetic animals remained unaltered. Serotonin (5-HT) concentrations were increased in PEVN of male and female diabetic rats. No significant changes in hypothalamic dopamine (DA) concentrations were observed. Insulin treatment reversed the diabetes-related changes in monoamine concentrations in most of the nuclei. The significance of these biochemical changes relative to the endocrine and behavioral abnormalities in diabetes is discussed. |
| | |
Authors:
|
M S Bitar; M Koulu; M Linnoila |
Related Documents
:
|
6482647 - Abnormalities in plasma catecholamine response and tissue catecholamine accumulation in... 12401717 - The iddm4 locus segregates with diabetes susceptibility in congenic wf.iddm4 rats. 3006217 - Kidney na,k-atpase activity in streptozotocin-diabetic rats. 14577587 - Dietary g-rutin suppresses glycation in tissue proteins of streptozotocin-induced diabe... 22050417 - Morphofunctional changes underlying intestinal dysmotility in diabetic rip-i/hifnβ tra... 16337207 - Effects of fenofibrate on apolipoprotein kinetics in patients with coexisting dysbetali... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Brain research Volume: 409 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1987 Apr |
Date Detail:
|
Created Date: 1987-07-16 Completed Date: 1987-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 236-42 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biogenic Amines / analysis* Diabetes Mellitus, Experimental / metabolism* Female Hydroxyindoleacetic Acid / analysis Hypothalamus / analysis* Insulin / therapeutic use Male Norepinephrine / analysis Rats Rats, Inbred Strains Serotonin / analysis Streptozocin |
| Chemical | |
Reg. No./Substance:
|
0/Biogenic Amines; 11061-68-0/Insulin; 18883-66-4/Streptozocin; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anterograde transsynaptic transport of WGA-HRP in rat olfactory pathways.
Next Document: Actions of convulsants, 4-aminopyridine and pentylenetetrazole, on the transient outward current of ...