Document Detail


Diabetes in Hong Kong Chinese: evidence for familial clustering and parental effects.
MedLine Citation:
PMID:  10977034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate transmission patterns of diabetes and their relationships with clinical characteristics in Hong Kong Chinese patients with late-onset (age > or =35 years) type 2 diabetes. RESEARCH DESIGN AND METHODS: This study involved 2,310 patients consecutively selected from a hospital clinic-based diabetes registry. These patients all reported the diabetes status of their parents as well as siblings. RESULTS: Approximately 36% of the 2,310 patients reported at least 1 affected parent or sibling (25 and 21% reported at least 1 diabetic parent and sibling, respectively). These patients, irrespective of their sex, were more likely to have a diabetic mother than a diabetic father (17 vs. 13% of the male patients and 18 vs. 9% of the female patients, P<0.01). The male patients were more likely than the female patients to have a diabetic father (13 vs. 9%, P<0.01). The female patients with a diabetic mother were found to have higher levels of plasma total cholesterol compared with the female patients with a diabetic father in multiple comparisons with adjustment for significance (5.56+/-1.30 vs. 5.09+/-0.95 mmol/l, P<0.05). In 2-group comparisons, there was also evidence that the male patients with a diabetic father had higher BMI values than the male patients with a diabetic mother (25.9+/-3.5 vs. 25.0+/-3.5 kg/m2, P<0.05). CONCLUSIONS: We found familial clustering of diabetes in the Hong Kong Chinese population as well as a significant maternal influence and a male sex-specific paternal effect. We suggest that both maternal and paternal factors may be implicated in the development of type 2 diabetes in the Chinese population.
Authors:
S C Lee; Y B Pu; C C Chow; V T Yeung; G T Ko; W Y So; J K Li; W B Chan; R C Ma; J A Critchley; C S Cockram; J C Chan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes care     Volume:  23     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-21     Completed Date:  2000-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1365-8     Citation Subset:  IM    
Affiliation:
Department of Medicine and Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, SAR. shaochin@ctimail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Asian Continental Ancestry Group / genetics*
Blood Pressure
China / ethnology
Diabetes Mellitus, Type 2 / epidemiology*,  genetics*
Female
Genomic Imprinting
Hemoglobin A, Glycosylated / analysis
Hong Kong / epidemiology
Humans
Male
Middle Aged
Nuclear Family*
Parents
Registries
Sex Characteristics
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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