| Diabetes, hyperglycemia and the management of cerebrovascular disease. | |
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MedLine Citation:
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PMID: 21124220 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Hyperglycemia is frequent in patients with cerebrovascular disease. This review article aims to summarize the recent evidence from observational studies that examined the adverse cerebrovascular effects of dysglycemic states as well as interventional studies assessing intensive management strategies for hyperglycemia. RECENT FINDINGS: In recent years, diabetes, prediabetic states and insulin resistance and their association with cerebrovascular disease were an important focus of research. The cerebrovascular consequences of these metabolic abnormalities were found to extend beyond ischemic stroke to covert brain infarcts, other structural brain changes and to cognitive impairment with and without dementia. Interventional studies did not reveal that more intensive management of chronic hyperglycemia and of hyperglycemia in the setting of acute stroke improves outcome. There is clear evidence, however, that the overall management of multiple risk factors and behavior modification in patients with dysglycemia may reduce the burden of cerebrovascular disease. SUMMARY: Observational studies reveal the growing burden and adverse cerebrovascular effects of dysglycemic states. Currently available interventional studies assessing more intensive strategies for the management of hyperglycemia did not prove, however, to be effective. We discuss the current evidence, pathophysiological considerations and management implications. |
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Authors:
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Salo Haratz; David Tanne |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current opinion in neurology Volume: 24 ISSN: 1473-6551 ISO Abbreviation: Curr. Opin. Neurol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9319162 Medline TA: Curr Opin Neurol Country: England |
Other Details:
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Languages: eng Pagination: 81-8 Citation Subset: IM |
Affiliation:
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Stroke Center, Department of Neurology, The Chaim Sheba Medical Center, Tel-Hashomer, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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