Document Detail

Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study.
MedLine Citation:
PMID:  23046078     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Women with polycystic ovary syndrome (PCOS) are potentially at increased risk of cardiovascular (CV) diseases due to well-established risk factors, including insulin resistance, obesity and type 2 diabetes mellitus (T2DM). However, data showing excess CV events in this population are still lacking. We investigated the incidence and prevalence of CV events in a cohort of women with PCOS.
DESIGN: Retrospective cohort study (total follow-up >12,000 person-years).
SETTING: Leicester, Leicestershire and Rutland (Total Female population of 434,859), UK.
PARTICIPANTS: Two thousand three hundred and one women with PCOS (mean age = 29.6 years) attending a speciality clinic in Leicestershire, UK.
MAIN OUTCOMES MEASURES: T2DM, myocardial infarction (MI), angina, heart failure (HF), stroke and CV-related death.
RESULTS: Incidence of T2DM, MI, angina, HF, stroke and CV death was respectively 3.6, 0.8, 1.0, 0.3, 0.0 and 0.4 per 1000 person-years. At the end of follow-up, the prevalence of MI in the age groups 45-54, 55-64 and >65 years was 1.9%, 6.0% and 27.3% and of angina was 2.6%, 6.0% and 27.3%, respectively. Age-group-specific odds ratios for the prevalence of MI and angina compared to the local female population ranged between 2.6 (95% CI: 1.0-6.3) and 12.9 (CI: 3.4-48.6) with the highest ratio being for MI in the group >65 years old. Age, history of hypertension and smoking had significant correlations with CV outcomes in the PCOS patients.
CONCLUSION: We have shown a high incidence and age-group-specific prevalence of T2DM, MI and angina in the women with PCOS, with over a quarter having had MI or angina in those >65 years. These findings should be considered in the treatment strategies and long-term planning for women with PCOS.
Hamidreza Mani; Miles J Levy; Melanie J Davies; Danielle H Morris; Laura J Gray; John Bankart; Hannah Blackledge; Kamlesh Khunti; Trevor A Howlett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-06
Journal Detail:
Title:  Clinical endocrinology     Volume:  78     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-10-28     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  926-34     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons Ltd.
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MeSH Terms
Angina Pectoris / epidemiology
Cardiovascular Diseases / epidemiology*,  etiology
Cohort Studies
Diabetes Mellitus, Type 2 / epidemiology*
Great Britain / epidemiology
Heart Failure / epidemiology
Middle Aged
Myocardial Infarction / epidemiology
Polycystic Ovary Syndrome / complications*,  epidemiology
Retrospective Studies
Stroke / epidemiology
Grant Support
RP-DG-1210-10183//Department of Health; RP-PG-0606-1272//Department of Health
Comment In:
Clin Endocrinol (Oxf). 2013 Jun;78(6):823-4   [PMID:  23362921 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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