| Diabetes affects statherin expression in human labial glands. | |
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MedLine Citation:
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PMID: 21718392 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Oral Diseases (2011) Background and Objective: Salivary statherin, which plays a special role in the defense of tooth integrity, is secreted by both major and minor salivary glands. A significantly reduced expression of this was recently found in human major salivary glands removed from diabetic subjects and was correlated with the high incidence of dental diseases occurring in patients with diabetes. In this study, we measured the density of gold particles indicating statherin immunoreactivity in labial glands to reveal a significant difference between diabetic and non-diabetic patients. Materials and Methods: Surgical samples of labial glands obtained from both diabetic and non-diabetic patients were fixed with a glutaraldehyde and paraformaldehyde mixture, embedded in Epon, and treated for immunogold histochemistry using a polyclonal antibody specific for statherin. Results: Statherin immunoreactivity was detected onto small vesicles diffused throughout the cytoplasm of serous cells. Statistical analysis revealed that the number of stained particles was significantly lower in the samples from diabetic subjects than from non-diabetic subjects. Conclusions: The results indicate that diabetes affects statherin secretion in labial glands and support the hypothesis that the increased susceptibility to oral diseases associated with diabetes could be related with a reduced statherin secretion. |
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Authors:
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M Isola; Ms Lantini; P Solinas; M Diana; R Isola; F Loy; M Cossu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-11 |
Journal Detail:
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Title: Oral diseases Volume: - ISSN: 1601-0825 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Cytomorphology, University of Cagliari, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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