| Diabetes treatment and progression of benign prostatic hyperplasia in community-dwelling black and white men. | |
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MedLine Citation:
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PMID: 22112286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To conduct a study to determine whether diabetes treatment is associated with benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and progression in black and white men. Diabetes has been associated with BPH and LUTS in aging men. METHODS: Using the Olmsted County Study of Urinary Symptoms and Health Status among Men and the Flint Men's Health Study, we examined how the use of medical therapy (eg, insulin regimens, oral hypoglycemics) related to changes in LUTS severity, maximal urinary flow rate measured by uroflowmetry, prostate volume determined by transrectal ultrasonography, and serum prostate-specific antigen concentrations. RESULTS: Of the 2226 men participating in the Olmsted County Study of Urinary Symptoms and Health Status among Men and the Flint Men's Health Study, 186 men reported a history of diabetes, 76.9% of whom were treated with medical therapy. Overall, the men with diabetes had significantly greater odds of moderate/severe LUTS (age- and race-adjusted odds ratio 1.37, 95% confidence interval 1.00-1.87) compared with those without diabetes. However, among the diabetic men, those not taking medication had greater odds of moderate/severe LUTS than those taking medication. This association among men not taking medication was seen for 5 of the 7 individual symptoms. The prostate volume and prostate-specific antigen level were not significantly associated with diabetes treatment. No significant differences were observed for the annual change in BPH characteristics by diabetes treatment status. CONCLUSION: These findings suggest that the presence of diabetes and subsequent poor glycemic control might be less related to prostate growth and more to the dynamic components of lower urinary tract function. Additional evaluations of the associations between glycemic control and BPH progression are warranted. |
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Authors:
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Aruna V Sarma; Jennifer L St Sauver; John M Hollingsworth; Debra J Jacobson; Michaela E McGree; Rodney L Dunn; Michael M Lieber; Steven J Jacobsen; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-11-23 |
Journal Detail:
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Title: Urology Volume: 79 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-28 Completed Date: 2012-02-27 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 102-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109-2800, USA. asarma@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans / statistics & numerical data* Age Distribution Aged Case-Control Studies Cohort Studies Confidence Intervals Diabetes Mellitus / diagnosis, drug therapy*, epidemiology*, ethnology Disease Progression European Continental Ancestry Group / statistics & numerical data* Follow-Up Studies Humans Hypoglycemic Agents / adverse effects*, therapeutic use Logistic Models Longitudinal Studies Male Middle Aged Multivariate Analysis Odds Ratio Prevalence Prostatic Hyperplasia / epidemiology*, ethnology, etiology, physiopathology Residence Characteristics Risk Assessment Severity of Illness Index United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG034676-47/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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