| Diabetes Mellitus Affects Biomechanical Properties of the Optic Nerve Head in the Rat. | |
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MedLine Citation:
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PMID: 22156545 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: To investigate the effect of diabetes on the biomechanical behavior of the optic nerve head (ONH) and the peripapillary sclera (ppSc) in streptozocine-induced diabetic rats. Methods: Diabetes mellitus was induced in 20 Wistar rats using streptozocine. Twenty-five nondiabetic rats served as controls. Eyes were enucleated after 12 weeks and 2 strips of one eye were prepared containing ONH or ppSc. The stress-strain relation was measured in the stress range of 0.05-10 MPa using a biomaterial tester. Results: At 5% strain the stress of the ONH in diabetic rats was 897 ± 295 kPa and in the control group it was 671 ± 246 kPa; there was a significant difference between both groups (p = 0.011). The stress of the diabetic ppSc (574 ± 185 kPa) increased compared to that of the nondiabetic ppSc (477 ± 171 kPa), but this did not reach statistical significance (p = 0.174). The calculated tangent modulus at 5% strain was 11.79 MPa in the diabetic ONH and 8.77 MPa in the nondiabetic ONH; there was a significant difference between both groups (p = 0.006). The calculated tangent modulus at 5% strain was 7.17 MPa in the diabetic ppSc and 6.12 MPa in the nondiabetic ppSc, without a statistically significant difference (p = 0.09). Conclusion: In contrast to the ppSc, the ONH of diabetic rats showed a significant increase in stiffness compared to nondiabetic rats, which might be explained by nonenzymatic collagen cross-linking mediated by advanced glycation end products due to high blood glucose levels in diabetes. Further studies are needed to investigate if these biomechanical changes represent a detrimental risk factor for intraocular pressure regulation in diabetic glaucoma patients. |
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Authors:
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Naim Terai; Eberhard Spoerl; Michael Haustein; Karin Hornykewycz; Janek Haentzschel; Lutz E Pillunat |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-07 |
Journal Detail:
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Title: Ophthalmic research Volume: 47 ISSN: 1423-0259 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: - |
Other Details:
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Languages: ENG Pagination: 189-194 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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