| Diabetes Genetic Predisposition Score and Cardiovascular Complications Among Patients With Type 2 Diabetes. | |
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MedLine Citation:
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PMID: 23069839 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVETo examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D.RESEARCH DESIGN AND METHODSThe current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetes-predisposing variants.RESULTSEach additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01). We also found that the GPS was positively associated with hemoglobin A(1c) levels (P = 0.009).CONCLUSIONSGenetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D. |
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Authors:
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Qibin Qi; James B Meigs; Kathryn M Rexrode; Frank B Hu; Lu Qi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-15 |
Journal Detail:
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Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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