| Diabetes Exacerbates Nanoparticles induced Brain Pathology. | |
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MedLine Citation:
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PMID: 22229323 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Long term exposure of nanoparticles e.g., silica dust (SiO2) from desert environment, or engineered nanoparticles from metals viz., Cu, Al or Ag from industry, ammunition, military equipment and related products may lead to adverse effects on mental health. However, this is unclear whether these nanoparticles may further adversely affect human health in situation in cardiovascular or metabolic diseases e.g., hypertension or diabetes. It is quite likely that in diabetes or hypertension where the body immune system is already compromised will have much adverse effects following nanoparticles exposure on human health as compared to their exposure to healthy individuals. Previous experiments from our laboratory showed that diabetic or hypertensive animals are more susceptible to heat stress-induced neurotoxicity. Furthermore, traumatic injury to the spinal cord in SiO2 exposed rats resulted in exacerbation of cord pathology. However, whether nanoparticle such as Cu, Ag or SiO2 exposure will lead to enhanced neurotoxicity in diabetic animals are still not well investigated. Previous data from our laboratory showed that Cu or Ag intoxication (50 mg/kg, i.p. per day for 7 days) in streptozotocine induced diabetic rats exhibited enhanced neurotoxicity and exacerbation of sensory, motor and cognitive function as compared to normal animals under identical conditions. Thus the diabetic animals showed exacerbation of regional blood-brain barrier (BBB) disruption, edema formation and cell injuries along with greater reduction in the local cebtral blood flow (CBF) as compared to normal rats. These observations suggest that diabetic animals are more vulnerable to nanoparticles induced brain damage than healthy rats. The possible mechanisms and functional significance of these findings are discussed in this review largely based on our own investigations. |
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Authors:
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J V Lafuente; A Sharma; R Patnaik; D F Muresanu; H S Sharma |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: CNS & neurological disorders drug targets Volume: - ISSN: 1996-3181 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101269155 Medline TA: CNS Neurol Disord Drug Targets Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anesthesiology & Intensive Care medicine, University Hospital, Uppsala University, SE-75185 Uppsala, Sweden. Sharma@surgsci.uu.se. |
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