Document Detail

Dextromethorphan and its combination with phenytoin facilitate kindling.
MedLine Citation:
PMID:  8492958     Owner:  NLM     Status:  MEDLINE    
We implanted 20 rats with bipolar electrodes and randomly distributed them into four groups that received intraperitoneal injections of phenytoin (PHT) (20 mg/kg), dextromethorphan (DM) (50 mg/kg), PHT+DM (20 and 50 mg/kg, respectively), or saline (C), 15 minutes before each daily stimulation. The number of stimulations needed to reach stage 3 seizures was 14.4 +/- 1.7 (C); 28 +/- 12 (PHT, p < 0.001); 6.2 +/- 3.9 (DM, p < 0.05); and 7.6 +/- 3.4 (PHT+DM, p < 0.05), suggesting that DM accelerated the expression of kindled seizures. Daily injections of DM and of DM+PHT without stimulation resulted in progressive seizure buildup to stage 3 in 4.8 +/- 6.2 (DM) or in 8 +/- 4.8 (DM+PHT) trials. We demonstrated savings in six kindled animals reinjected after 1 month. These results and previous experimental and clinical data suggest that DM may be epileptogenic when given repeatedly in high doses.
K W Thompson; C G Wasterlain
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  43     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-11     Completed Date:  1993-06-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  992-4     Citation Subset:  AIM; IM    
Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343.
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MeSH Terms
Dextromethorphan / pharmacology*
Drug Interactions
Electric Stimulation
Hippocampus / drug effects,  physiology,  physiopathology
Kindling, Neurologic / drug effects*
Phenytoin / pharmacology*
Rats, Sprague-Dawley
Seizures / chemically induced,  physiopathology*
Grant Support
Reg. No./Substance:
125-71-3/Dextromethorphan; 57-41-0/Phenytoin
Comment In:
Neurology. 1994 Mar;44(3 Pt 1):582-3   [PMID:  8179707 ]

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